Rapid Erasure of Long-Term Memory Associations in the Cortex by an Inhibitor of PKMz

نویسندگان

  • Reut Shema
  • Todd Charlton Sacktor
  • Yadin Dudai
چکیده

87, 1988 (1990). 6. M. Zhen, Y. Jin, Nature 401, 371 (1999). 7. K. Shen, R. D. Fetter, C. I. Bargmann, Cell 116, 869 (2004). 8. T. Cardozo, M. Pagano, Nat. Rev. Mol. Cell Biol. 5, 739 (2004). 9. K. I. Nakayama, K. Nakayama, Nat. Rev. Cancer 6, 369 (2006). 10. A. DiAntonio et al., Nature 412, 449 (2001). 11. M. D. Ehlers, Nat. Neurosci. 6, 231 (2003). 12. R. J. Watts, E. D. Hoopfer, L. Luo, Neuron 38, 871 (2003). 13. M. Zhen, X. Huang, B. Bamber, Y. Jin, Neuron 26, 331 (2000). 14. A. M. Schaefer, G. D. Hadwiger, M. L. Nonet, Neuron 26, 345 (2000). 15. L. Dreier, M. Burbea, J. M. Kaplan, Neuron 46, 51 (2005). 16. E. H. Liao, W. Hung, B. Abrams, M. Zhen, Nature 430, 345 (2004). 17. S. Jager, H. T. Schwartz, H. R. Horvitz, B. Conradt, Proc. Natl. Acad. Sci. U.S.A. 101, 12549 (2004). 18. E. J. Hubbard, G. Wu, J. Kitajewski, I. Greenwald, Genes Dev. 11, 3182 (1997). 19. D. H. Lee, A. L. Goldberg, Trends Cell Biol. 8, 397 (1998). 20. R. J. Deshaies, Annu. Rev. Cell Dev. Biol. 15, 435 (1999). 21. C. L. Waites, A. M. Craig, C. C. Garner, Annu. Rev. Neurosci. 28, 251 (2005). 22. S. D. Speese, N. Trotta, C. K. Rodesch, B. Aravamudan, K. Broadie, Curr. Biol. 13, 899 (2003). 23. A. N. Hegde, A. DiAntonio, Nat. Rev. Neurosci. 3, 854 (2002). 24. M. Colledge et al., Neuron 40, 595 (2003). 25. P. Juo, J. M. Kaplan, Curr. Biol. 14, 2057 (2004). 26. A. DiAntonio, L. Hicke, Annu. Rev. Neurosci. 27, 223 (2004). 27. B. Bingol, E. M. Schuman, Nature 441, 1144 (2006). 28. We thank CGC, Japanese NBPR, Y. Kohara, M. Nonet, and J. Audhya for reagents. Supported by NIH grant 1R01NS048392 (K.S.), the McKnight endowment fund (K.S.), the W. M. Keck Foundation (K.S.), and the Searle Scholarship (K.S.).

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تاریخ انتشار 2009