Rapid Erasure of Long-Term Memory Associations in the Cortex by an Inhibitor of PKMz
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87, 1988 (1990). 6. M. Zhen, Y. Jin, Nature 401, 371 (1999). 7. K. Shen, R. D. Fetter, C. I. Bargmann, Cell 116, 869 (2004). 8. T. Cardozo, M. Pagano, Nat. Rev. Mol. Cell Biol. 5, 739 (2004). 9. K. I. Nakayama, K. Nakayama, Nat. Rev. Cancer 6, 369 (2006). 10. A. DiAntonio et al., Nature 412, 449 (2001). 11. M. D. Ehlers, Nat. Neurosci. 6, 231 (2003). 12. R. J. Watts, E. D. Hoopfer, L. Luo, Neuron 38, 871 (2003). 13. M. Zhen, X. Huang, B. Bamber, Y. Jin, Neuron 26, 331 (2000). 14. A. M. Schaefer, G. D. Hadwiger, M. L. Nonet, Neuron 26, 345 (2000). 15. L. Dreier, M. Burbea, J. M. Kaplan, Neuron 46, 51 (2005). 16. E. H. Liao, W. Hung, B. Abrams, M. Zhen, Nature 430, 345 (2004). 17. S. Jager, H. T. Schwartz, H. R. Horvitz, B. Conradt, Proc. Natl. Acad. Sci. U.S.A. 101, 12549 (2004). 18. E. J. Hubbard, G. Wu, J. Kitajewski, I. Greenwald, Genes Dev. 11, 3182 (1997). 19. D. H. Lee, A. L. Goldberg, Trends Cell Biol. 8, 397 (1998). 20. R. J. Deshaies, Annu. Rev. Cell Dev. Biol. 15, 435 (1999). 21. C. L. Waites, A. M. Craig, C. C. Garner, Annu. Rev. Neurosci. 28, 251 (2005). 22. S. D. Speese, N. Trotta, C. K. Rodesch, B. Aravamudan, K. Broadie, Curr. Biol. 13, 899 (2003). 23. A. N. Hegde, A. DiAntonio, Nat. Rev. Neurosci. 3, 854 (2002). 24. M. Colledge et al., Neuron 40, 595 (2003). 25. P. Juo, J. M. Kaplan, Curr. Biol. 14, 2057 (2004). 26. A. DiAntonio, L. Hicke, Annu. Rev. Neurosci. 27, 223 (2004). 27. B. Bingol, E. M. Schuman, Nature 441, 1144 (2006). 28. We thank CGC, Japanese NBPR, Y. Kohara, M. Nonet, and J. Audhya for reagents. Supported by NIH grant 1R01NS048392 (K.S.), the McKnight endowment fund (K.S.), the W. M. Keck Foundation (K.S.), and the Searle Scholarship (K.S.).
منابع مشابه
The genetics of PKMz and memory maintenance
Elucidating the molecular mechanisms that maintain long-term memory is a fundamental goal of neuroscience. Accumulating evidence suggests that persistent signaling by the atypical protein kinase C (PKC) isoform protein kinase Mz (PKMz) might maintain synaptic long-term potentiation (LTP) and long-term memory. However, the role of PKMz has been challenged by genetic data from PKMz-knockout mice ...
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تاریخ انتشار 2009